Intravaginal pentamycin for the treatment of bacterial vaginosis
نویسندگان
چکیده
منابع مشابه
Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis.
Microporous, poly (ɛ-caprolactone) (PCL) matrices loaded with the antibacterial, metronidazole were produced by rapidly cooling suspensions of drug powder in PCL solutions in acetone. Drug incorporation in the matrices increased from 2.0% to 10.6% w/w on raising the drug loading of the PCL solution from 5% to 20% w/w measured with respect to the PCL content. Drug loading efficiencies of 40-53% ...
متن کاملSafety, tolerability and pharmacokinetics of intravaginal pentamycin.
BACKGROUND/AIMS Intravaginal pentamycin is a polyene macrolide with a broad spectrum of antimicrobial activity and is effective in various forms of infectious vaginitis. We evaluated the safety, tolerability and pharmacokinetics of escalating doses of this product. METHODS Nineteen healthy volunteers were randomized to receive double blind one of five doses of intravaginal pentamycin (3, 10, ...
متن کاملLocal treatment for bacterial vaginosis.
Bacterial vaginosis (non-specific vaginitis) is a mild but common condition. O'Dowd et al reported that organisms associated with vaginosis could be isolated from 37% of women who presented with vaginal symptoms. The current treatment of choice is an oral nitroimidazole (metronidazole or tinidazole), given either as a single large dose or as a twice daily regimen for five to seven days. A probl...
متن کاملTinidazole in the treatment of bacterial vaginosis
Bacterial vaginosis (BV) is the commonest cause of vaginal discharge in women of childbearing age. Oral metronidazole has long been established as an effective therapy in the treatment of BV. However, adverse effects due to metronidazole are frequent and this may lead to problems with adherence to a 7-day course of treatment and subsequently result in treatment failure. Oral tinidazole has been...
متن کاملComparative Study of Intravaginal Metronidazole and Triple-Sulfa Therapy for Bacterial Vaginosis
OBJECTIVE We sought to compare the efficacy of metronidazole gel vs. triple-sulfa cream in the treatment of bacterial vaginosis (BV). METHODS In a double-blinded study, 247 women with symptomatic BV were randomly assigned to receive either 5 g of 0.75% metronidazole gel twice daily for 5 days or triple-sulfa cream twice daily for 5 days. There were 205 (96 treated with metronidazole and 109 t...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2010
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2010.02.1920